Recent comments in /f/science

chrisdh79 OP t1_jeensqv wrote

Reply to A new drug called AF-130 has been developed that offers “two-for-one” treatment of heart failure and sleep apnea by targeting the nervous activity that drives both. by chrisdh79

From the article: Now, a promising new drug has been developed that targets the nerve activity that causes both heart failure and sleep apnea. Researchers from the University of Auckland in New Zealand tested the drug, known as AF-130, on rats with chronic heart failure and sleep apnea. They found that AF-130 acted as an effective P2X3 receptor antagonist, normalizing the body’s respiratory response to hypoxia and substantially improving the amount of blood pumped by the heart (cardiac output). Breathing disturbances were eliminated.

“This drug does offer benefit for heart failure, but it’s two for the price of one, in that it’s also relieving the apnea for which there is currently no drug, only CPAP, which is poorly tolerated,” said Julian Paton, corresponding author of the study.

AF-130 was also found to reduce systemic inflammation, reduce the weight of the heart, and prevent fluid from gathering in the lungs (pulmonary edema), a common side effect of heart failure. It’s the first drug to control the brain-to-heart nervous activity that drives heart failure and associated sleep apnea.

The study’s findings support the notion that P2X3 receptors in the carotid arteries play a key role in the pathological mechanisms underlying cardiovascular and respiratory diseases.

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Durhai t1_jeenqub wrote

Reply to Adding 1 ounce (28.35 g) of walnuts to the usual dietary intake of no-nut consumers improved the diet quality among children, adolescents, and adults. by ludwig_scientist

Walnuts are tasty and nutritious, but have a lot of fats, good fats, but still fats. A 1 ounce serving has 190 calories composed of 20g of fat and nearly 6g of protein. Moderation is needed when consuming calorie dense foods.

I eat walnuts every morning as I have found them to be the easiest of the nut varieties to purchase in bulk and to consume. I try to limit my intake to around 20g. I have convinced myself that I’ve seen a positive impact in the way I feel since I started eating them daily some months ago. I don’t know if they’re having a huge impact upon my health or not, but I’ll continue to eat them as I enjoy their added crunch and texture in my morning oatmeal.

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Reply to A new drug called AF-130 has been developed that offers “two-for-one” treatment of heart failure and sleep apnea by targeting the nervous activity that drives both. by chrisdh79

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ghsgjgfngngf t1_jeemyv1 wrote

Reply to comment by Brain_Hawk in A systematic review and meta-analysis finds yoga has a moderately positive effect on the improvement of depressive symptoms but also their severity. by empty-ego

I'm sure that the effect is real and also that it would probably be comparable to many other interventions that are activities (and not something like handing them a leaflet). It's exercise and of course exercise has a positive effect.

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MonkAndCanatella t1_jeejint wrote

Reply to comment by CaptainHindsight92 in Sublingual Spray With THC And CBD Can Control Blood Sugar, Lowers Cholesterol In Type 2 Diabetes Patients by Defiant_Race_7544

  1. Research and acceptance has been stifled by the drug war for so long, you'd be lucky to get funding for research. now it's established as worth the money so the funding has been flowing more freely.
  2. The plant actually does have the miraculous properties and probably even more unknown benefits.
  3. There are definitely some scam artists trying to make a buck on it, but that's true of anything a scam artist thinks they can make a buck on.
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