Recent comments in /f/science

iceyed913 t1_jdwhfef wrote

trueee, but in combating the yoyo effect you would desensitize a mechanism and this would result in a lifelong treatment plan. Might just be preferable to use the old ozempic if it proves to be safe longterm. Although adjuncts are always nice if all else fails.

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Zadarex OP t1_jdwemof wrote

Highlights

  • Forced loss lowers social ranks and induces depressive-like behaviors
  • Forced loss generates negative reward prediction error
  • Forced loss but not natural loss activates LH-LHb circuit and induces LHb bursting
  • LHb burst firing inhibits mPFC and reinforces subordination

Summary

Downward social mobility is a well-known mental risk factor for depression, but its neural mechanism remains elusive. Here, by forcing mice to lose against their subordinates in a non-violent social contest, we lower their social ranks stably and induce depressive-like behaviors. These rank-decline-associated depressive-like behaviors can be reversed by regaining social status. In vivo fiber photometry and single-unit electrophysiological recording show that forced loss, but not natural loss, generates negative reward prediction error (RPE). Through the lateral hypothalamus, the RPE strongly activates the brain’s anti-reward center, the lateral habenula (LHb). LHb activation inhibits the medial prefrontal cortex (mPFC) that controls social competitiveness and reinforces retreats in contests. These results reveal the core neural mechanisms mutually promoting social status loss and depressive behaviors. The intertwined neuronal signaling controlling mPFC and LHb activities provides a mechanistic foundation for the crosstalk between social mobility and psychological disorder, unveiling a promising target for intervention.

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Wagamaga OP t1_jdwdagy wrote

A cup of wild blueberries a day may keep low energy at bay. The berries have long been hailed as a superfood—while they’re known for a plethora of health benefits, new research from Cal Poly Humboldt proves this superfruit could help burn fat during exercise.

The study, recently published in the journal Nutrients and the first to examine wild blueberries’ fat-burning effects during exercise in non-elite athletes, suggests that wild blueberries may help accelerate fat oxidation—the process of breaking down fatty acids or burning fats for energy.

The study included 11 healthy aerobically trained males. Each was instructed to follow a diet, which included consuming 25 grams of freeze-dried wild blueberries (equivalent to 1 cup of raw fruit) daily for two weeks. Participants exercised on a bike for 40 minutes at Cal Poly Humboldt’s Human Performance Lab. Researchers collected urine and blood before and after cycling, and blood samples every 10 minutes during the workout.

Results showed participants burned notably more fat after consuming wild blueberries. For example, fat oxidation rate rose by 19.7%, 43.2%, and 31.1% at 20, 30, and 40 min after cycling.

Overall, the research found that consuming roughly 1 cup of wild blueberries daily for two weeks increases the ability to use/burn fat during moderate-intensity exercise, like cycling.

While it accelerates fat burning, it also decreases the use of carbohydrates. Burning more fat while using less carbs is significant for athletes, explains Cal Poly Humboldt Kinesiology Professor Taylor Bloedon, the study’s lead researcher.

“Increasing the use of fat can help performance, particularly in endurance activities as we have more fat stores to keep us going longer than we do carb stores,” says Bloedon. “Saving stored carbs also helps when we need to increase our intensity, often towards the end of the race or training session, or when challenged by an opponent. At these higher intensities we cannot rely on fat to fuel us as fat cannot be used as a fuel source for high-intensity activities.”

https://www.newswise.com/articles/study-suggests-wild-blueberries-help-burn-fat

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1

Hodlisforthepoor0x OP t1_jdwapl9 wrote

TL;DR - A new study suggests that the ability to care about others may have originated millions of years ago in prehistoric animals before fish and mammals diverged on the tree of life. Researchers found that fish can detect fear in other fish and become afraid too, a behaviour regulated by oxytocin, the same brain chemical that underlies the capacity for empathy in humans. The study also showed that zebrafish pay more attention to fish that have previously been stressed out, a behaviour the researchers likened to consoling them. The research suggests that oxytocin's role in transmitting emotion is an "ancestral role" that may have been in place around 450 million years ago.

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OzzyMan4444 t1_jdw7yan wrote

Interesting to think what this would do to their mitochondria, as that DNA is all maternal in nature. Does it just take the last female ancestors mitochondria? Does this cause potential stress on that organelle to the point that it can cause inherited diseases? Still really cool (and potentially frightening) technology!

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marilern1987 t1_jdw7b2r wrote

The problem is that there isn’t anything wrong with most of the studies, but HOW they are interpreted

A lot of things I see in this subreddit are legit - but the average person doesn’t always interpret it correctly.

For example: this past weekend, the article about birth control and breast cancer. Look at the comments on that post - a lot of the comments on that post failed to read the article, or interpret the results correctly. Meanwhile, birth control has been a known carcinogen for people with certain genetic makeups since 2007, but a lot of the comments were like “guess we’re screwed either way…”

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