And not a single mention of the causes of these deaths. What a pointless article.

No, those are the percentage risks of developing breast cancer for two different age groups, who BOTH took birth control. Using hormonal birth control in later life carries a higher risk of breast cancer, but as the percentages illustrate, the absolute risk is still low.

What's your evidence for this claim?

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Suking is the only safe activity, it seems...

I'll give you a cheat sheet in case your wife dies and leaves 65-69 year old you alone:

Know how to cook

Know how to keep a house clean and orderly

Know how to do laundry

Know how/when to make doctor's appointments

And take your goddamn medicine!

Honestly, I'm pretty sure it's the whole "men refuse to see a doctor unless their wives force them to" thing that does them in. Why are y'all like this?

Yeah cuz he no longer has a live-in life coach monitoring his every drink, every smoke, every late night. Nothing to stop from staying up until dawn thanks to lines of good coke snorted off a $200/hr stripper's belly. Pizza at 4am. Driving fast. A recipe for disaster. After an appropriate mourning period of course.

I work at a hospital. The amount of times an old man has answered the question "What medicines do you take?" With "I don't know, but my wife has a list." Makes my head spin. Sir, you are 60 years old and you can't keep track of a medicine list on your own?

Game night with the gents at the retirement home

Actual article title:

>Study examines straight men and their sexual attraction to transgender women

Having skimmed the actual study, I definitely read some of those posts at some point. I think there are straight identified guys who are realizing they are attracted more towards feminine presentations and not just cisgender women. Unfortunately, the misogyny they have for ciswomen also tracks with transwomen, with the added stereotypes of transwomen that come from their experience of transwomen being what they see online (my guess).

In the span of less than a decade, my views on trans people went from being pretty much a few casual stereotypes, to knowing/working with a few, to being in a relationship with a transwoman for several years now. I likely held some of the same stereotypes of transwomen until I actually worked with some in real life and got to see them as actual people, which makes the intended erasure of trans people we see all the more harmful.

Err how true is this.

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For anyone worried about this you can limit exposure by buying Jasmine/Basmati rice grown in California. Although more pricey there have been studies that show they have much lower levels of arsenic and heavy metals than most other sources

The transmission of OXPHOS disease and methods to prevent this ( 2005)

>Despite extensive studies on use of various pharmacological agents and vitamin supplements, there is still no cure for OXPHOS disease. Pharmacological therapy mainly relies on the administration of artificial electron acceptors, metabolites and cofactors or oxygen radical scavengers (Dimauro et al., 2004).

>Physical exercise can also be important to prevent disease manifestations. Most patients with mitochondrial disease are inactive because of exercise intolerance or fear for muscle damage, in spite of the fact that aerobic training increases work and oxidation capacity in these patients (Taivassalo et al., 2001; Taivassalo and Haller, 2004).

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Ew. That’s a very simplistic and wrong way to look at this issue. You don’t cure endometriosis or PCOS with a good diet and exercise. There is no cure, but hormonal contraception can make life more bearable and manageable. I honestly don’t know how you can come into this thread and make this claim when you clearly don’t know what you’re talking about

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So, for the layman... Obesity makes some cancer worse and /or more prevalent? Or harder to treat? What's STING stimulation?

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Highlights

•Obesity establishes an IFN-I-deprived tumor microenvironment and increases tumor burden

•Myeloid cells from obese hosts are desensitized to STING stimulation

•Saturated fatty acids inhibit the STING pathway by inducing NLRC3

• NLRC3 inhibits the immunogenicity of HNSCC in an IFN-I-dependent fashion

Summary

Oncogenes destabilize STING in epithelial cell-derived cancer cells, such as head and neck squamous cell carcinomas (HNSCCs), to promote immune escape. Despite the abundance of tumor-infiltrating myeloid cells, HNSCC presents notable resistance to STING stimulation. Here, we show how saturated fatty acids in the microenvironment dampen tumor response to STING stimulation. Using single-cell analysis, we found that obesity creates an IFN-I-deprived tumor microenvironment with a massive expansion of suppressive myeloid cell clusters and contraction of effector T cells. Saturated fatty acids, but not unsaturated fatty acids, potently inhibit the STING-IFN-I pathway in HNSCC cells. Myeloid cells from obese mice show dampened responses to STING stimulation and are more suppressive of T cell activation. In agreement, obese hosts exhibited increased tumor burden and lower responsiveness to STING agonist. As a mechanism, saturated fatty acids induce the expression of NLRC3, depletion of which results in a T cell inflamed tumor microenvironment and IFN-I-dependent tumor control.

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