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Abstract: >Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative phosphorylation (OxPhos) activity, but its pathophysiological role in neurodegeneration remains unclear. Here, we show that the brain critically depends on astrocytic OxPhos to degrade fatty acids (FAs) and maintain lipid homeostasis. Aberrant astrocytic OxPhos induces lipid droplet (LD) accumulation followed by neurodegeneration that recapitulates key features of Alzheimer’s disease (AD), including synaptic loss, neuroinflammation, demyelination and cognitive impairment. Mechanistically, when FA load overwhelms astrocytic OxPhos capacity, elevated acetyl-CoA levels induce astrocyte reactivity by enhancing STAT3 acetylation and activation. Intercellularly, lipid-laden reactive astrocytes stimulate neuronal FA oxidation and oxidative stress, activate microglia through IL-3 signalling, and inhibit the biosynthesis of FAs and phospholipids required for myelin replenishment. Along with LD accumulation and impaired FA degradation manifested in an AD mouse model, we reveal a lipid-centric, AD-resembling mechanism by which astrocytic mitochondrial dysfunction progressively induces neuroinflammation and neurodegeneration.

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

My mom died of breast cancer and I’ll never use hormonal birth control again for this reason.

Thing is usually men die first anyway. Ots quite rare than husband oulive his wife.

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Do you take a vaccine every day tho?

This was me! I had ocular migraines regularly while on estrogen birth control and my PCP didn’t make the connection. I switched doctors and the second one immediately referred me to a neurologist, who said it wasn’t safe for me to be on that birth control anymore- the ocular migraines were a signal my body wasn’t responding well.

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A lot of those issues can be helped by lifestyle, diet and exercise. People want a pill to fix things, but sometimes it creates more issues, like cancer.

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While that may generally be a reasonable hormone free approach to birth control, there's also the implications of women using hormonal contraceptives for menstrual related issues (ex: endometriosis, PCOS, severe PMS, hormonal acne) etc. Seems it's just one more risk to weigh against the benefits and this is disappointing news for a lot of women.

Edit - typo

Many stop taking medications

Human activity can cause climate change too. It doesn't take much to trigger something bigger.

Hookers and blow? I mean if I’m 69 and single that’s a great way to go…

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Kill her when you're 64?

wouldnt that just be because of lonleiness?

danish men can't cook, so they starve

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Not entirely true. Ultimately all lobular and ductal cancers derive from hormone-positive normal cells. There are hormone negative tumors, but they develop negativeity after multiple generations. Such tumros tend to more often are found in older women, as well.

The study found that women who had ever used hormonal contraceptives had a slightly increased risk of breast cancer, with an absolute excess risk of 8 per 100,000 users from age 16 to 20 years and 265 per 100,000 users from age 35 to 39 years.

This means that out of 100,000 women who have never used hormonal contraceptives, about 8 women will develop breast cancer in their lifetime. Out of 100,000 women who have ever used hormonal contraceptives, about 9 women will develop breast cancer in their lifetime.

The study also has some limitations. First, it is a retrospective study, which means that the researchers cannot be sure that the hormonal contraceptives caused the breast cancer. Second, the study only looked at women who had been diagnosed with breast cancer, so it is not clear whether the findings would be the same for women who had not been diagnosed with breast cancer. Third, the study did not look at the specific types of hormonal contraceptives that were used, so it is not clear whether the findings would be the same for all types of hormonal contraceptives.

that’s 0.008% to 0.265% increased risk over those who did not use hormonal birth control