Recent comments in /f/science
AutoModerator t1_jdetdas wrote
Reply to By combining a robotic system with a beehive, scientists successfully warmed and resurrected a honeybee colony experiencing a perilous winter condition called chill-coma. The “robotic beehive” also let researchers monitor heat patterns and map colony activity. by FillsYourNiche
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.
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dumpsterbaby2point0 t1_jdet4st wrote
Reply to By combing through genomic data of over 1 million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used, the findings also reinforce the role of the dopamine system in addiction by giuliomagnifico
I’m pretty sure I’ve never met a person with addiction issues that didn’t also have ADHD/ADD. If we could do better with diagnosis and holistic/family-based treatment for kids as young as possible, the positive impact could be astounding.
HorrorCharacter5127 OP t1_jdeste0 wrote
Reply to comment by terraresident in For the first time, autism is being diagnosed more frequently in Black and Hispanic children than in white kids in the U.S., the Centers for Disease Control and Prevention said Thursday. by HorrorCharacter5127
It is not from 2010. This study is from this year, 2023.
cornerofgraystreet t1_jdesnd9 wrote
Reply to comment by iam666 in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
I'm simply talking about the lack of research, due to legal impediments prohibiting research at the most basic levels. I'm talking about research involving all parts of the cannabis plant as a whole. Blanket statement. Not JUST CBD. Simple as that....
terraresident t1_jdeshbf wrote
Reply to For the first time, autism is being diagnosed more frequently in Black and Hispanic children than in white kids in the U.S., the Centers for Disease Control and Prevention said Thursday. by HorrorCharacter5127
Studies from 2010.....Millions of children of color who did not have healthcare back then are now covered. No story here.
Lemonio t1_jderugs wrote
Reply to comment by roodeeMental in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
What do you smoke? I have neuropathic pain and had wanted to try it but wasn’t sure what to get and how much. Also since my neuropathic pain is in the throat I’d probably do edibles, but there was a lot of different products and I was confused
iam666 t1_jderhe0 wrote
Reply to comment by cornerofgraystreet in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
Are you referring to CBD research not being allowed, or just general research on “health conditions”?
Because in either case I don’t know what you’re talking about. You’re literally looking at a study about using CBD to treat a health condition.
SaltZookeepergame691 t1_jdeqvnq wrote
Reply to comment by ddx-me in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
It’s also a very high dose injected directly into the spine.
Good RCTs into this question could have been done years ago, but most are terrible. I’ll believe a substantial pain modulating effect when it’s proven (and if there is one, it will be easy to do so).
zacktoronto t1_jdeqdom wrote
Reply to comment by Redneck2Researcher in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
Can you elaborate?
CY_Royal t1_jdeqcgd wrote
Reply to comment by lalalandland in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico
I have had a similar experience with a gluten allergy and anxiety/panic
lalalandland t1_jdepzg0 wrote
Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico
I am oversensitive to gluten. I get anxiety when I accidentally eat gluten. It's manifests as panic attack and after a while I become really fatigued. A few years ago I realized the cause of this an my life is so much better when I avoid gluten. Now I have much more energy and I don't have a constant lingering anxiety
ddx-me t1_jdeppk0 wrote
Abstract
Objectives: This study aimed to investigate the effect of cannabidiol (CBD) on type 4 Toll-like receptors (TLR4), glial cells and pro-inflammatory cytokines during the neuropathic pain induced by the chemotherapy agent paclitaxel (PTX), as well as the involvement of the endocannabinoid system in this process.
Methods: Male C57BL6 mice were subjected to PTX-induced neuropathic pain. To evaluate the involvement of the TLR4, glial cells and cannabinoid CB2 receptor, specific inhibitors or antagonists were intrathecally administered. The western blotting and immunofluorescence assay was performed to evaluate the spinal expression of TLR4, microglia, astrocytes and cannabinoid CB2 receptor. The levels of spinal pro-inflammatory cytokines and endocannabinoids were determined by enzyme-linked immunosorbent assay and liquid chromatography-mass spectrometry analysis, respectively.
Key findings: CBD prevented PTX-induced neuropathic pain, and the cannabinoid CB2 receptor antagonist AM630 reversed this effect. In addition, CBD treatment inhibited the spinal expression of TLR4 and Iba1 in mice with neuropathic pain. CBD also increased spinal levels of endocannabinoids anandamide and 2-arachidonoylglycerol, and reduced levels of cytokines in mice with neuropathic pain.
Conclusions: CBD was efficient in preventing PTX-induced neuropathic pain, and this effect may involve inhibition of the TLR4 on microglia spinal with activation of the endocannabinoid system.
Keywords: cannabidiol; glial cells; neuropathic pain; pro-inflammatory cytokines.
My commentary - while encouraging, rats can't really tell us if they're having pain. Will need to test CBD versus a placebo in randomized trial to truly see if there is actual pain relief clinically.
AutoModerator t1_jdepfmx wrote
Reply to For the first time, autism is being diagnosed more frequently in Black and Hispanic children than in white kids in the U.S., the Centers for Disease Control and Prevention said Thursday. by HorrorCharacter5127
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
SnooPuppers1978 t1_jdep519 wrote
Reply to comment by sf_sf_sf in A Swedish study found elite male soccer players are 1.5 times more likely to develop neurodegenerative disease compared to population controls. A previous study from Scotland suggested that soccer players were 3.5 times more likely to develop neurodegenerative disease. by Wagamaga
We should compare them to some other athletes like runners for example.
jbindel t1_jdenvls wrote
Reply to comment by bluebook21 in Canada scientists create new method to break down toxic ‘forever chemicals’ | University of British Columbia researchers develop silica-based material with ability to absorb wider range of harmful chemicals by Hrmbee
“To destroy the chemicals, Mohseni says researchers use either electrochemical or photochemical processes to break the carbon-fluorine bond.”
Cannonballbmx t1_jdemen7 wrote
Reply to comment by FollowTheFauchi in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico
Interesting fact, you can actually have a migraine in your stomach. My son has had stomach issues we’ve been trying to address with his doctor and this is one of the things we tried to control with a certain medication.
slickhedstrong t1_jdel1y2 wrote
Reply to comment by WitloofDSV in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico
i always assumed it was because the neurons in your gut work in tandem with the neuron in your brain. the guy has the second most amount of neurons in the body.
in my mind that's why we get "gut feelings" and would explain butterflies and why we thought love was any abdomen thing rather than a brain thing
Saltine_Machine t1_jdel1ga wrote
Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico
It's funny... I am reading this while my anixety is through the roof and my ibs is acting up... by funny I mean I'm sad.
roodeeMental t1_jdekrzw wrote
Reply to comment by Redneck2Researcher in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544
So yes, for a lot of things. CBD works on your CB2 receptors, which your peripheral nervous is loaded in. CB1 are mainly in the central nervous system, and loaded around places like you hippocampus in humans, which THC clings to. In other animals its different, so you'll find weed will mess with co-ordination a lot more. I personally for my condition need the whole package, and not just CBD
CBD is more like a muscle relaxant when soley used.
At least this is what I remember reading a while back
veltcardio2 t1_jdejmko wrote
Reply to comment by SuppaCoup in Phase 1 study: New medicine extends terminally-ill cancer patients' lives. Seventy percent of the patients who tested the medicine were stable after six weeks. Twelve continued the medication and were stable for 18 weeks. One woman took the medication for 17 months, and was stable for over two years by Wagamaga
Oncologist here. This is a phase 1 trial, it can’t assess efficacy, there is no comparator here. Phase 1 trial exist to asses optimal dosage and safety, side effects, etc. Before it reaches a phase 3 trial (where it would be compared against another established therapy), it needs more testing. It’s too early to even know if it works and even it’s side effects, but it looks like something that should be further studied.
veltcardio2 t1_jdeiyq8 wrote
Reply to comment by SaltZookeepergame691 in Phase 1 study: New medicine extends terminally-ill cancer patients' lives. Seventy percent of the patients who tested the medicine were stable after six weeks. Twelve continued the medication and were stable for 18 weeks. One woman took the medication for 17 months, and was stable for over two years by Wagamaga
This is the correct comment. Needs more research and even more trials before efficacy trials. Too early
Narcan9 t1_jdeifvc wrote
Reply to By combing through genomic data of over 1 million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used, the findings also reinforce the role of the dopamine system in addiction by giuliomagnifico
The addiction system must have been an evolutionary Advantage for it to be so prevalent today. I suspect it has to do with something like thrill seeking and impulsiveness making for better warriors and increasing the chance of surviving deadly conflicts.
Those traits may not be as well suited for a more peaceful, agrarian society.
FillsYourNiche OP t1_jdeteoc wrote
Reply to By combining a robotic system with a beehive, scientists successfully warmed and resurrected a honeybee colony experiencing a perilous winter condition called chill-coma. The “robotic beehive” also let researchers monitor heat patterns and map colony activity. by FillsYourNiche
Journal article A robotic honeycomb for interaction with a honeybee colony.
Abstract:
>Robotic technologies have shown the capability to interact with living organisms and even to form integrated mixed societies composed of living and artificial agents. Biocompatible robots, incorporating sensing and actuation capable of generating and responding to relevant stimuli, can be a tool to study collective behaviors previously unattainable with traditional techniques. To investigate collective behaviors of the western honeybee (Apis mellifera), we designed a robotic system capable of observing and modulating the bee cluster using an array of thermal sensors and actuators. We initially integrated the system into a beehive populated with about 4000 bees for several months. The robotic system was able to observe the colony by continuously collecting spatiotemporal thermal profiles of the winter cluster. Furthermore, we found that our robotic device reliably modulated the superorganism’s response to dynamic thermal stimulation, influencing its spatiotemporal reorganization. In addition, after identifying the thermal collapse of a colony, we used the robotic system in a “life-support” mode via its thermal actuators. Ultimately, we demonstrated a robotic device capable of autonomous closed-loop interaction with a cluster comprising thousands of individual bees. Such biohybrid societies open the door to investigation of collective behaviors that necessitate observing and interacting with the animals within a complete social context, as well as for potential applications in augmenting the survivability of these pollinators crucial to our ecosystems and our food supply.