AutoModerator t1_jde1sa5 wrote on March 23, 2023 at 6:51 PM

Reply to By combing through genomic data of over 1 million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used, the findings also reinforce the role of the dopamine system in addiction by giuliomagnifico

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

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terpin t1_jde1kh7 wrote on March 23, 2023 at 6:50 PM

Reply to comment by roodeeMental in CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

Neuropathic pain is insane, I had such an insane level of it I didn't even know I was experiencing headaches. I recently found out I have an atypical migraine disorder that was disrupting my whole body, literally crippling me, to the point they thought I had a brain tumor, intercranial hypertension, MS or some esoteric autoimmune disease this last year.

A neurologist gave me topiramate to see if it could get rid of the visual snow I got after I caught covid (which kicked off all this), and instead it turned off a lot of my pain. It's been like a godsend. My dominant hand was rated disabled by my OT and was completely recovered within a month a starting treatment. My vision is recovering, it's so crazy.

I even had this weird issue where I'd been peeing fire for a year, and it was gone. No one thought it might be a brain problem, they just told me it was because my diet was bad. So nuts. Glad you found something that worked for you, no one should live with that pain.

[deleted] t1_jde0ibr wrote on March 23, 2023 at 6:43 PM

Reply to CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

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roodeeMental t1_jddxvtr wrote on March 23, 2023 at 6:27 PM

Reply to CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

I suffer with a rare form of neuralgia- a type of neuropathic pain

It started one day age 24, and left me unable to talk though the pain, or function - unimaginable pain. Neurologists started with sedatives, then gabapentin, yet nothing helped really. I started smoking weed, and as long as I kept up frequent use, it turned down the pains by 95%. Now I live a normal life again, sorta

Edit: I wrote a post about my neuralgia if anyone's interested

HTMntL t1_jddv8ce wrote on March 23, 2023 at 6:10 PM

Reply to CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

But big pharma doesn’t get a piece…

[deleted] t1_jddt1dt wrote on March 23, 2023 at 5:56 PM

Reply to CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

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[deleted] t1_jddsgb4 wrote on March 23, 2023 at 5:52 PM

Reply to New research finds when small talk becomes awkward, we are more likely to blame ourselves by chrisdh79

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FollowTheFauchi t1_jdds8x2 wrote on March 23, 2023 at 5:51 PM

Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

might explain migranes

bluebook21 t1_jddrtdw wrote on March 23, 2023 at 5:48 PM

Reply to Canada scientists create new method to break down toxic ‘forever chemicals’ | University of British Columbia researchers develop silica-based material with ability to absorb wider range of harmful chemicals by Hrmbee

Then what do you do with the toxin saturated silica?

AutoModerator t1_jddr50h wrote on March 23, 2023 at 5:44 PM

Reply to CBD Was Efficient In Preventing Chemotherapy-Induced Neuropathic Pain by Defiant_Race_7544

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

[deleted] t1_jddqbbd wrote on March 23, 2023 at 5:39 PM

Reply to comment by BassJerky in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

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[deleted] t1_jddlct7 wrote on March 23, 2023 at 5:08 PM

Reply to Dietary gluten worsens hepatic steatosis by increasing inflammation and oxidative stress in ApoE−/− mice fed a high-fat diet by Meatrition

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peakzorro t1_jddhc46 wrote on March 23, 2023 at 4:43 PM

Reply to comment by sonoma95436 in Canada scientists create new method to break down toxic ‘forever chemicals’ | University of British Columbia researchers develop silica-based material with ability to absorb wider range of harmful chemicals by Hrmbee

At least there is hope to get some of it out of the environment as we phase out forever chemicals.

[deleted] t1_jddgtt3 wrote on March 23, 2023 at 4:39 PM

Reply to Phase 1 study: New medicine extends terminally-ill cancer patients' lives. Seventy percent of the patients who tested the medicine were stable after six weeks. Twelve continued the medication and were stable for 18 weeks. One woman took the medication for 17 months, and was stable for over two years by Wagamaga

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[deleted] t1_jddg8vx wrote on March 23, 2023 at 4:36 PM

Reply to comment by FrozenToonies in Canada scientists create new method to break down toxic ‘forever chemicals’ | University of British Columbia researchers develop silica-based material with ability to absorb wider range of harmful chemicals by Hrmbee

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[deleted] t1_jddg30y wrote on March 23, 2023 at 4:35 PM

Reply to comment by Hrmbee in Canada scientists create new method to break down toxic ‘forever chemicals’ | University of British Columbia researchers develop silica-based material with ability to absorb wider range of harmful chemicals by Hrmbee

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SaltZookeepergame691 t1_jddc88t wrote on March 23, 2023 at 4:10 PM

Reply to comment by DeathRebirth in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

That’s not what this study is suggesting. And we already know IBS is a syndrome related to disordered gut-brain interaction - that’s why the umbrella terminology for these conditions is literally “disorders of gut-brain interaction”.

This study shines a closer light on the specific cellular mechanisms that might be involved in IBS discomfort/pain, which provides targets for specific therapies at the level of the gut - they are specifically looking at hyperactivation of enterochromaffin cells, which are neuronal cells embedded in the gut wall, that then signal to gut neurons and ultimately produce visceral pain reactions.

Edit: the serotonin signalling modulator they use as proof-of-principle in the model is alosetron, which is only used in very severe IBS in women (it was withdrawn from all other indications due to side effects). Trust me - they are not suggesting that everyone take systemic alosetron, they are not stupid:

>Data presented here also support a role for local, rather than systemic serotonergic signalling at the interface between EC cells and mucosal afferents, consistent with recent suggestions that primary afferent nerve fibres form synapse-like associations with enteroendocrine cells. Alosetron, which is approved for the treatment of severe IBS with diarrhoea in women39, has been proposed to exert its analgesic effect centrally or through inhibition of high-threshold nociceptors in the gut wall. We propose an alternative or further mechanism to account for this sex-biased analgesic effect, namely one involving modulation of serotonergic signalling at EC cell–mucosal afferent circuits.

[deleted] t1_jdda2sl wrote on March 23, 2023 at 3:57 PM

Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

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[deleted] t1_jdd9iv5 wrote on March 23, 2023 at 3:53 PM

Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

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WanderingJaguar t1_jdd94u9 wrote on March 23, 2023 at 3:51 PM

Reply to comment by DeathRebirth in Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

I agree, I don't think a treatment that shuts down that brain gut communication is a healthy solution.

DeathRebirth t1_jdd3t82 wrote on March 23, 2023 at 3:17 PM

Reply to Study has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for irritable bowel syndrome and anxiety by giuliomagnifico

Directly linking the nerve pathway to a syndrome like IBS is risky in my mind. IBS diagnosises are given out like candy as well as a buffet of different treatments, and then saying "you likely have IBS, try repressing your main channel between gut and brain" seems like a recipe for longer term health issues.

Not saying the study is bad or the conclusions about the importance of this pathway, but the immediate treatment links that a title like this suggests are not so great.

I say this as someone that suffers from IBD, likely recurrent SIBO, and possibly some IBS mechanism separate to the former 2 issues. No matter what treatment I receive, I still have constant recurrent pain, but I would still be hesitant to inhibit this pathway directly...