Recent comments in /f/science

No_Masterpiece679 t1_jchmlpy wrote

Reply to People with dark personality traits are better in finding novel ways to cause damage or harm others: Study reveals that people with more pronounced dark personality traits tend to have more malevolent creativity by DreamingForYouAlways

I just watched the Netflix show “outlast” and it was rather eye opening with how this latent ability to be cruel manifests in some people. Others refused to be a part of it.

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Reply to Loss of Menin helps drive the aging process, and dietary supplement can reverse it in mice by geoxol

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pcream t1_jchby3w wrote

Reply to comment by Coly1111 in A new targeted drug has not only sparked remissions in patients with a common form of leukemia but also induced the cancer cells to reveal one of their schemes for resisting the drug, according to a new study by chrisdh79

CML is generally well treated with kinase inhibitors and, as far as I know, there are no planned trials for menin inhibitors. Menin inhibitors work for NPM1 and MLL rearrangement leukemias because they both drive the cancer by overexpression of pro-growth/survival genes, such as HOX family genes. Both mutations work by epigenetically deregulating the regions around these genes, such as the HOXA locus. The inhibition of menin, a protein cofactor needed for this epigenetic deregulatory process, counteracts the abnormal expression of these genes by preventing the epigenetic changes from occurring. While there is some evidence (I found with a brief search) that HOX genes are aberrantly expressed in CML, it doesn't appear to be crucial for the leukemia to survive. So it is unlikely that a menin inhibitor would be effective, but without preclinical testing, we don't know that for sure.

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youritalianjob t1_jchb7dj wrote

Reply to comment by MissingScore777 in Poor sleep in middle age can have a negative impact on brain health, according to a study by researchers at The Australian National University by chrisdh79

Pretty much my experience as well except I'm closer to a 50/50 split. I usually get around 5-6 hours most nights myself but definitely need more based on how I feel throughout the day. I haven't gotten a full 8 in a few years.

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