Recent comments in /f/science

motogucci t1_jcfcm40 wrote

But it won't affect the warming levels of co2 this side of the industrial revolution.

Before we started burning fossil fuels, there was this thing called a carbon cycle. Carbon gets emitted by lifeforms, through various methods including decay, as well as by digestion/respiration. And that same exact carbon gets recollected by lifeforms, usually plants. Those plants were collectively eaten by animals, or decayed straightaway, and were the cyclical source of the carbon in the air, just as well as being the cyclical recovery system.

If we removed what you might call a carbon bank, such as a tropical forest, then we've disrupted that original carbon cycle (in addition to the harm from burning fossil fuels). If we put the forest back, it isn't undoing our industrial revolution. It's only returning a proper piece of that slightly older carbon cycle.

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dharkmeat t1_jcfccmi wrote

From OPs reference: "The researchers did not investigate the sweetener’s effects in humans, and say that it is unlikely that normal consumption of sucralose is harmful."

  1. This is a relatively naive comment and underestimates diet soda *addiction*, certainly in the US.
  2. The singular conclusion that sucralose can help replace immunosuppression therapies - without addressing the obvious question, what is the effect of sucralose on the global immunosuppression of its users, seems to be a missed opportunity. It follows that we would want to understand if we have a public health issue not so much whether we have a new immunosuppression therapy.

Edit: minor grammar

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Kradget t1_jcf9ehn wrote

We currently have very large sections of land that aren't really being used for agriculture (or are being used for very inefficient ways of growing food) that we could return to local native grassland. We can't solve a huge problem with only one solution, but we can make dents in it (through things like habitat restoration) that will help in combination with changes to our behaviors and upcoming technology.

We can't just plant trees and get out of this if that's all we do. But it'll help. Same as we can't just switch to solar and resolve every problem, even if that will help.

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CogitusCreo t1_jcf92tx wrote

Inability to fall back to sleep after waking at night was mildly negatively associated with dementia, but didn't seem very significant. Inability to fall asleep at the start of the night was significantly associated with developing dementia.

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panairesdoas t1_jcf682o wrote

This study is a great reminder of the importance of getting enough sleep - especially in middle age. Poor sleep has been linked to a variety of health issues, including brain health, and this research provides further evidence that sleep is an important factor in overall health and wellbeing. It's definitely something to keep in mind as we age and take steps to ensure we get enough quality sleep.

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chrisdh79 OP t1_jcf4el6 wrote

From the article: The study looked at the sleep habits of over 29,000 people aged between 37 and 73 and could provide the basis for helping to combat major diseases like dementia.

According to lead author and PhD candidate Dr Tergel Namsrai, it’s not just lack of sleep that can impair brain health.

“Getting more than nine hours of sleep a day or less than six hours were both associated with lower brain volume and cognitive measures – crucial for things like reaction time and memory,” Dr Namsrai said.

“Daytime dozing was also associated with some of these indicators of impaired brain health.”

Dr Namsrai said there needs to be greater focus on the links between sleep and brain health, as well as more research into ways to improve sleep.

“The mechanisms underlying the link between sleep and brain health are not well understood – there’s a lot of work to be done,” she said.

“But our study shows it could be an important target if we want to improve brain health into old age and delay the onset of dementia."

Dementia is among the world’s leading causes of death worldwide and is expected to impact 150 million people by 2050.

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chrisdh79 OP t1_jcf4589 wrote

From the article: One of the papers presents results of a clinical trial in which approximately 40% of patients with acute leukemia subtypes had a complete response – a disappearance of all signs of cancer – to treatment with the drug revumenib. The other paper uncovers a molecular countermove by which leukemia cells come to sidestep the drug and reassert their growth.

The papers point to the promise of the targeted approach to acute leukemia treatment exemplified by revumenib and to the potential to extend its benefits with drugs that trip up the resistance mechanism, researchers say.

"The two genetic subtypes of acute leukemia involved in this research account for approximately 40% of all cases of acute myeloid leukemia (AML) in children and adults," says Scott Armstrong, MD, PhD, president of the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and co-senior author of the paper on revumenib resistance. "They're driven by a rearrangement of the MLL1 gene or a mutation in the NPM1 gene. Both types depend on a protein called menin to sustain their growth."

The first of the new Nature studies reports on a phase I/II clinical trial of the drug revumenib, which targets menin, in 68 patients with acute leukemia that wasn't responding other therapies. The trial, dubbed the AUGMENT-101 study, found that of 60 patients who could be evaluated, 53% responded to the drug and 30% had a complete response.

"For patients with acute leukemia who have undergone several previous treatments, this is a very encouraging result," Armstrong says. "However, after the second cycle of treatment, some patients did develop resistance to revumenib."

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gabbertr0n t1_jcf42fr wrote

I’m interested in this term ‘hierarchical thinking’ and I see you paired it with magical thinking - I’m keen to understand these terms more, in relation to the conspiracy theorists we are discussing - if you would be so kind to explain, thank you.

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1