Recent comments in /f/science

Ian_Campbell t1_jc8sqeu wrote

Reply to comment by williaty in Statins May Decrease Heart Disease in People With Sleep Apnea, according to new study by chrisdh79

I'm fully compliant, got my thyroid treated within range, and I'm still getting horrible sleep by how I feel during the day. No hormone panel results like low testosterone or low cortisol. Every day I'm tired in the morning and getting up is a longer process with the machine because waking up isn't enough, whereas when you wake up with no machine you're kind of ready to go.

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quantumgpt t1_jc8rv0y wrote

Reply to comment by BlueSkyToday in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

I will be ordering an extract and cutting it with coconut oil until it's at my tolerance level and then include (R)ALA in my diet, as well as continue my carnitine. I mean I will to to do what it takes and I don't mind the discomfort during the day. It's when it's 3am and I'm bouncing my foot and tying knots around my toe to help with the pain just to sleep. It's rather annoying.

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williaty t1_jc8qhup wrote

Reply to comment by estranho in Statins May Decrease Heart Disease in People With Sleep Apnea, according to new study by chrisdh79

As a fellow CPAP user that's really dug into the details on therapy, my instant suspicion is this: How well controlled are they looking at for "on CPAP therapy"? The clinical threshold for successful therapy is an AHI of 5 or below. However, there's LOTS of patient reports saying that getting from untreated down to an AHI of 5 didn't actually make them feel better. It's pretty common to see patient reports of symptom improvements in the AHI 1-2 range. So if the study is considering people treated/compliant/on therapy at AHI <=5 but the physiologically significant threshold is AHI <=1.5 or something, that's a LOT of people who are "treated" but not actually going to have better outcomes.

Additionally, it's sadly common for patients to start therapy successfully, both in the clinical sense of AHI<5 but also in terms of feeling better but then slowly drift out of the desired range as they gain weight, age, or have other life changes. Again, this could be producing a large cohort that's being counted as treated in the study but isn't getting the health benefits.

But yeah, this worries me too and I'd like to see more detailed investigation.

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cygnoids t1_jc8nhb5 wrote

Reply to comment by luisvel in Cancer researchers show introducing bacteria to a tumour’s microenvironment creates a state of acute inflammation that triggers the immune system’s primary responder cells to attack rather than protect a tumour. by unswsydney

My assumption is you need to balance stimulating the immune system and causing a severe infection. I need to read the paper to see if it was full bacterial lysate or if you could take some PAMPs to stimulate an immune response

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BlueSkyToday t1_jc8ndnl wrote

Reply to New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

Does an 8% patch hurt?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755533/

> Patients were prepared for the patch with 4% lidocaine cream that was applied for 1 h prior to treatment. The capsaicin 8% patch (NGX-4010) was applied for 60 min to a maximum area of 1000 cm2. In the dose-ranging study, it was applied for 30, 60 and 90 min [Webster et al. 2010]. Treatment-related pain was dealt with by local cooling methods and oral oxycodone (1 mg/ml). In the first week after treatment, hydrocodone bitartrate/acetaminophen (5 mg/500 mg) was allowed as rescue medication up to day 5 only.

If you're not familiar with analgesics, stacking hydrocodone with acetaminophen is a common practice.

Is 5mg of hydrocodone a lot? Let me put it this way, 10 mg every 12 hours is for 'severe pain',

https://www.mayoclinic.org/drugs-supplements/hydrocodone-oral-route/proper-use/drg-20084881

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BlueSkyToday t1_jc8lzxx wrote

Reply to comment by quantumgpt in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

I can't imagine that there's any chemical difference between the capsaicin in the patches and the capsaicin in OTC products.

Here's a link to a paper discussing the 8% patches,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755533/

In relation to pain from the patch, this part might be what people are looking for,

> Patients were prepared for the patch with 4% lidocaine cream that was applied for 1 h prior to treatment. The capsaicin 8% patch (NGX-4010) was applied for 60 min to a maximum area of 1000 cm2. In the dose-ranging study, it was applied for 30, 60 and 90 min [Webster et al. 2010]. Treatment-related pain was dealt with by local cooling methods and oral oxycodone (1 mg/ml). In the first week after treatment, hydrocodone bitartrate/acetaminophen (5 mg/500 mg) was allowed as rescue medication up to day 5 only.

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Colonel_hernia t1_jc8l8zv wrote

Reply to Researchers: Floating solar panels could provide over a third of global electricity by TurretLauncher

as amore amore. amore. amore. amore. to amore. amore. amore. This article is talking about installing solar panels over artificial bodies of water (like reservoirs), not covering our oceans with solar farms, which is interesting considering the extent to which we trash our oceans on a daily basis for reasons far worse than clean energy.

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