Recent comments in /f/science

Ghost-of-Tom-Chode t1_jc5jn1q wrote

Reply to comment by YawnTractor_1756 in Confirmed: Global floods, droughts worsening with warming by besselfunctions

I agree in general. However, everything is actually getting worse. As you said, even if it’s only 10%, or whatever percentage it is. What’s it going to be in another 50 years? Another hundred years? I wish I could say I think it will get better, but everything seems to be slowly rotting (at best).

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unswsydney OP t1_jc5iic1 wrote

Reply to Cancer researchers show introducing bacteria to a tumour’s microenvironment creates a state of acute inflammation that triggers the immune system’s primary responder cells to attack rather than protect a tumour. by unswsydney

Afternoon r/science! A team of UNSW and Garvan Institute researchers have found that introducing bacteria to a tumour’s microenvironment creates a state of acute inflammation that triggers the immune system’s primary responder cells to attack rather than protect a tumour.

The research could lead to better treatments to improve outcomes for people with advanced or previously untreatable cancers.

The work has been published in the journal Cancer Research, and is available to read here: https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-21-4025/716558/Neutrophil-conversion-to-a-tumor-killing-phenotype

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Reply to Cancer researchers show introducing bacteria to a tumour’s microenvironment creates a state of acute inflammation that triggers the immune system’s primary responder cells to attack rather than protect a tumour. by unswsydney

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NoNumbersAtTheEnding t1_jc5gv3u wrote

Reply to comment by tyler1128 in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79

I opened this notification while I was rather busy but I’mma find the paper when I have the time/tomorrow if I forget before going to sleep.

Feel free to respond again calling me out if I don’t do that. I just have ADHD and autism so it’s easy for stuff like this to slip my mind

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AirmedTuathaDeDanaan t1_jc5dik7 wrote

Reply to Researchers have contributed to the largest ever genetic study of endometriosis, finding 42 genetic regions associated with endometriosis paving the way for new treatments. by No_Peanut_7102

The biggest problem is that most doctors don't believe women in pain. I had this debilitating pain for so many years, I had to pass 4 doctor before finding 1 that believe I was in pain and knew it wasn't "just normal periods".

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YawnTractor_1756 t1_jc5dabi wrote

Reply to comment by throwawaypizza012 in Confirmed: Global floods, droughts worsening with warming by besselfunctions

50 years ago people knew what happens in their vicinity in details, in their country in general and in the world superficially.

Today people know what happens in every corner of the world on a daily basis.

Paired with natural proclivity for paying more attention to bad news, people now have convenient endless stream of bad news from all around the world. Something somewhere is always bad: something is flooding, burning, breaking, failing, dying.

No wonder that despite things are overall maybe 10% worse, people perceive them to be 120% worse.

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Brain_Hawk t1_jc58ayp wrote

Reply to comment by DrCunningLinguistPhD in Researchers have contributed to the largest ever genetic study of endometriosis, finding 42 genetic regions associated with endometriosis paving the way for new treatments. by No_Peanut_7102

"Identified signals explained up to 5.01% of disease variance "

I'm not going to read a whole genetics paper. I'm not saying it's bad research, this sort of work is important. But it is often oversold. They identified a candidate set of genes using a large publicly available data set, which often has minimal patient specific information on most disorders. I should have read more of the abstract but I stopped, I'm pretty sure they ran a gwas. Those identify associations but not causes. They're an important start point, but it's a very far lead from identifying. Some genes that are related to is disorder with a relatively small effect size and to building a treatment target that has any widespread application

I'm not stating any objection to what the researchers did, but I have a long standing objection to results like this being massively oversold both in the media and by the scientists themselves. It's very tempting, especially if you get a splash in nature paper. But it builds a lot of false hope, and it's unlikely that any of these candidate genes will see clinical trials and the next 10 years if ever

The most positive outcome for these papers, In my not too humble opinion , is that the identify potential targets for future more directed studies, they can examine the association with those specific genes with that disorder in detail

Edit: Happy the abstract says that too, more targeted studies are needed to confirm and better understand these associations

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